國立臺南大學專任教師基本資料
姓名陳韋妤
系所生態暨環境資源學系
校內分機7799
EMAILwychen@mail.nutn.edu.tw
辦公室榮譽校區ZC105-4
網址https://wychen7.wixsite.com/omega-lab/
專長/研究領域水域生態毒理、計算毒理學、毒理動力/毒理動態模擬、生態風險評估
學位畢業學校國別主修學門修業期間
博士國立臺灣大學臺灣生物環境系統工程學所2007/09-2011/06
著作名稱:Bayesian population physiologically-based pharmacokinetic model for robustness evaluation of withdrawal time in tilapia aquaculture administrated to florfenicol
年度:2021
類別: 期刊論文 Ecotoxicology and Environmental Safety
摘要:The antimicrobial residues of aquacultural production is a growing public concern, leading to reexamine the method for establishing robust withdrawal time and ensuring food safety. Our study aims to develop the optimizing population physiologically-based pharmacokinetic (PBPK) model for assessing florfenicol residues in the tilapia tissues, and for evaluating the robustness of the withdrawal time (WT). Fitting with published pharmacokinetic profiles that experimented under temperatures of 22 and 28 °C, a PBPK model was constructed by applying with the Bayesian Markov chain Monte Carol (MCMC) algorithm to estimate WTs under different physiological, environmental and dosing scenarios. Results show that the MCMC algorithm improves the estimates of uncertainty and variability of PBPK-related parameters, and optimizes the simulation of the PBPK model. It is noteworthy that posterior sets generated from temperature-associated datasets to be respectively used for simulating residues under corresponding temperature conditions. Simulating the residues under regulated regimen and overdosing scenarios for Taiwan, the estimated WTs were 12-16 days at 22 °C and 9-12 days at 28 °C, while for the USA, the estimated WTs were 14-18 and 11-14 days, respectively. Comparison with the regulated WT of 15 days, results indicate that the current WT has well robustness and resilience in the environment of higher temperatures. The optimal Bayesian population PBPK model provides effective analysis for determining WTs under scenario-specific conditions. It is a new insight into the increasing body of literature on developing the Bayesian-PBPK model and has practical implications for improving the regulation of food safety.
關鍵字:Florfenicol; Tilapia; Bayesian analysis; Markov chain Monte Carlo; Physiologically-based pharmacokinetic model