| 編號： | 2 |
| 期刊或研討會名稱： |
J Ethnopharmacol
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| 著作名稱： | The properties of Ocicmum gratissimum aqueous extract against ultraviolet-C-induced inflammation
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| 年度： | 2026 |
| 類別： |
期刊論文
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| 摘要： | Ethnopharmacological relevance: Ocimum gratissimum L. commonly known as basil, is an herb-like plant frequently mentioned in ethnopharmacological studies due to its widespread availability in local communities and its widespread use in treating inflammatory conditions. In a previous study, we demonstrated that aqueous extracts of Ocimum gratissimum (OGE), which are rich in plant polyphenols such as caffeic acid and isoflavones, can protect skin cells from UVC-induced inflammation and damage in migration and proliferation.
Aim of the study: Building on these findings, this study aims to investigate the anti-inflammatory effects of OGE on UVC-treated DNA damage and its dermatological treatment potential in a mouse model.
Materials and methods: Wounds were treated with UVC alone or in combination with OGE, and healing outcomes were monitored over an 11-day period. Key assessments included wound appearance, wound area reduction, healing rates, and DNA damage markers.
Results: UVC exposure prolonged the healing time of incisions to 10.00 ± 0.82 days, compared to 7.25 ± 1.26 days in the no-UVC group. However, co-treatment with 0.6 % OGE significantly reduced the healing time to 8.00 ± 1.15 days. After 24 h of UVC irradiation, keratinocytes (a marker of DNA damage) in epidermis were approximately 97.5 % cyclobutane pyrimidine dimer (CPD)-positive in the UVC-only group but decreased to 52.5 % in the 0.6 % OGE + UVC group. Experiments in vitro using HaCaT cells demonstrated that OGE pretreatment significantly preserved cell viability and promoted wound closure during UVC exposure, in addition to reducing UVC-induced PARP activity (a marker for cell apoptosis). Liquid chromatograph/mass spectrometric (LC-MS) and Immunohistochemical (IHC) analyses further revealed that OGE increased levels of protective proteins, such as syntaxin-3, in UVC-treated HaCaT cells and mouse skin tissue. Notably, OGE did not interfere with UVCs toxicity against Escherichia coli (E. coli).
Conclusion: These findings suggest that OGE may serve as an effective prophylactic intervention against UVC-induced side effects by enhancing anti-oxidative and anti-inflammatory responses, thereby promoting tissue repair during surgical site disinfection. |
| 關鍵字： | Escherichia coli; HaCaT cells; Ocimum gratissimum aqueous extracts (OGE); Ultraviolet-C (UVC); Wound healing. |
| 編號： | 1 |
| 期刊或研討會名稱： |
European Poultry Science
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| 著作名稱： | Effects of dietary supplements with phytogenics and Rhodovulum sulfidophilum on laying performance and egg yolk cholesterol and triglyceride of laying hens
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| 年度： | 2026 |
| 類別： |
期刊論文
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| 摘要： | In this study, we determined the effects of a dietary supplement with phytogenics and photosynthetic bacteria Rhodovulum Sulfidophilum (RS) on the laying performance of hens. A total of 2,664 white leghorn laying hens aged 51 weeks were used. The hens were divided into three groups randomly, including control (basal diet), phytogenic (basal diet with 0.4 % phytogenic supplement), and RS (basal diet with 0.4 % RS supplement) groups. The experiments of 5-week durations revealed that both the phytogenic and RS groups showed significantly increased daily egg production by 4.0 % and 5.6 %, respectively (P 0.05) as well as exhibited significantly lower egg yolk cholesterol by 9.7 % and 12.3 %, respectively, and lower triglyceride levels by 12.5 % and 12.2 %, respectively (P 0.05). Therefore, we suggest phytogenics and RS as potential dietary supplements for laying hens. |
| 關鍵字： | Egg quality, Laying hen, Laying performance, Rhodovulum sulfidophilum, Phytogenics |